Drug interactions
Enalapril-hydrochlorothiazide + Porfimer
Severity: Moderate
Enalapril-hydrochlorothiazide and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides are photosensitising agents, and porfimer causes marked photosensitivity after photodynamic therapy. Combined use may increase the risk of skin phototoxic reactions.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitising effects.
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period advised after porfimer. Consider whether hydrochlorothiazide can be withheld during this period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Porfimer
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Porfimer?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides are photosensitising agents, and porfimer causes marked photosensitivity after photodynamic therapy. Combined use may increase the risk of skin phototoxic reactions.
How serious is the interaction between Enalapril-hydrochlorothiazide and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period advised after porfimer. Consider whether hydrochlorothiazide can be withheld during this period.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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