Drug interactions
Enfortumab vedotin + Ribociclib
Severity: Moderate
Enfortumab vedotin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload of enfortumab vedotin, MMAE, is a CYP3A4 substrate, and CYP3A4 inhibitors may raise free MMAE exposure. Because the antibody-drug conjugate releases little free MMAE, the effect is likely small, though neutropenia and neuropathy could be affected.
What this interaction means in plain words
Enfortumab vedotin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enfortumab vedotin belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, which could reduce clearance of the released MMAE.
What to do
Monitor blood counts and peripheral neuropathy closely during combined therapy. Manage toxicity by interrupting or reducing enfortumab vedotin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Ribociclib?
MediHelp rates the interaction as moderate. Enfortumab vedotin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of enfortumab vedotin, MMAE, is a CYP3A4 substrate, and CYP3A4 inhibitors may raise free MMAE exposure. Because the antibody-drug conjugate releases little free MMAE, the effect is likely small, though neutropenia and neuropathy could be affected.
How serious is the interaction between Enfortumab vedotin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and peripheral neuropathy closely during combined therapy. Manage toxicity by interrupting or reducing enfortumab vedotin.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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