Drug interactions
Ensitrelvir + Simvastatin
Severity: Contraindicated
Ensitrelvir and Simvastatin: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ensitrelvir greatly increases simvastatin exposure through CYP3A inhibition. This raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Ensitrelvir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
Why it happens
CYP3A inhibition prevents extensive first-pass metabolism of simvastatin.
What to do
Stop simvastatin at least 12 hours before the first ensitrelvir dose and do not restart during therapy. Consider a non-CYP3A statin if lipid control is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Ensitrelvir with Simvastatin?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ensitrelvir greatly increases simvastatin exposure through CYP3A inhibition. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Ensitrelvir and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop simvastatin at least 12 hours before the first ensitrelvir dose and do not restart during therapy. Consider a non-CYP3A statin if lipid control is needed.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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