Drug interactions
Entacapone + Pacritinib
Severity: Minor
Entacapone and Pacritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized by CYP3A4, and strong inhibitors raise its exposure and the risk of QT prolongation, bleeding and diarrhea. Entacapone is not an established CYP3A4 inhibitor, so the interaction is theoretical.
What this interaction means in plain words
Entacapone and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by entacapone; not established clinically.
What to do
No empirical dose change is needed; monitor for pacritinib adverse effects including bleeding and QT changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Entacapone with Pacritinib?
MediHelp rates the interaction as minor. Entacapone and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pacritinib is metabolized by CYP3A4, and strong inhibitors raise its exposure and the risk of QT prolongation, bleeding and diarrhea. Entacapone is not an established CYP3A4 inhibitor, so the interaction is theoretical.
How serious is the interaction between Entacapone and Pacritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for pacritinib adverse effects including bleeding and QT changes.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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