Drug interactions
Entecavir + Plazomicin
Severity: Moderate
Entecavir and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin, an aminoglycoside, can cause nephrotoxicity. A decline in renal function could increase entecavir concentrations, and entecavir requires dose adjustment in renal impairment.
What this interaction means in plain words
Entecavir and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Plazomicin belongs to Anti Bacterial.
Why it happens
Aminoglycoside nephrotoxicity reduces the renal elimination of entecavir.
What to do
Monitor serum creatinine during plazomicin therapy and adjust the entecavir dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entecavir
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Entecavir with Plazomicin?
MediHelp rates the interaction as moderate. Entecavir and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin, an aminoglycoside, can cause nephrotoxicity. A decline in renal function could increase entecavir concentrations, and entecavir requires dose adjustment in renal impairment.
How serious is the interaction between Entecavir and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during plazomicin therapy and adjust the entecavir dose to renal function.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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