Drug interactions
Enzalutamide + Etravirine
Severity: Major
Enzalutamide and Etravirine: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs induce CYP3A4 and are substrates of it, so each may lower the other's exposure. Reduced etravirine levels risk loss of virologic control and resistance, and enzalutamide efficacy may also fall.
What this interaction means in plain words
Enzalutamide and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Mutual CYP3A4 induction increases clearance of both drugs.
What to do
Avoid the combination where possible and choose an alternative antiretroviral regimen. If unavoidable, monitor HIV viral load and clinical response to enzalutamide closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Enzalutamide with Etravirine?
MediHelp rates the interaction as major. Enzalutamide and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs induce CYP3A4 and are substrates of it, so each may lower the other's exposure. Reduced etravirine levels risk loss of virologic control and resistance, and enzalutamide efficacy may also fall.
How serious is the interaction between Enzalutamide and Etravirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antiretroviral regimen. If unavoidable, monitor HIV viral load and clinical response to enzalutamide closely.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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