Drug interactions
Enzalutamide + Fosaprepitant
Severity: Moderate
Enzalutamide and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, which is metabolized by CYP3A4. Enzalutamide may lower aprepitant exposure and reduce antiemetic efficacy. Single-dose IV use is less affected than repeated oral dosing.
What this interaction means in plain words
Enzalutamide and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Enzalutamide induces CYP3A4, increasing aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting and add other antiemetics if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Enzalutamide with Fosaprepitant?
MediHelp rates the interaction as moderate. Enzalutamide and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, which is metabolized by CYP3A4. Enzalutamide may lower aprepitant exposure and reduce antiemetic efficacy. Single-dose IV use is less affected than repeated oral dosing.
How serious is the interaction between Enzalutamide and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add other antiemetics if needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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