Drug interactions
Enzalutamide + Haloperidol
Severity: Moderate
Enzalutamide and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong inducer of CYP3A4 and can speed up the clearance of haloperidol, which is partly metabolized by this enzyme. Plasma haloperidol concentrations may fall, leading to reduced antipsychotic control and possible relapse of symptoms.
What this interaction means in plain words
Enzalutamide and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Haloperidol belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4 (and other enzymes), increasing the hepatic and intestinal metabolism of haloperidol.
What to do
Monitor psychiatric response and consider increasing the haloperidol dose if symptoms re-emerge. Reassess the dose if enzalutamide is stopped, because haloperidol levels will rise again.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Haloperidol?
MediHelp rates the interaction as moderate. Enzalutamide and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong inducer of CYP3A4 and can speed up the clearance of haloperidol, which is partly metabolized by this enzyme. Plasma haloperidol concentrations may fall, leading to reduced antipsychotic control and possible relapse of symptoms.
How serious is the interaction between Enzalutamide and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider increasing the haloperidol dose if symptoms re-emerge. Reassess the dose if enzalutamide is stopped, because haloperidol levels will rise again.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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