Drug interactions
Enzalutamide + Liposomal doxorubicin
Severity: Minor
Enzalutamide and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and could in theory lower exposure to doxorubicin. However, CYP3A4 is a minor route for doxorubicin clearance, so the clinical effect is probably small and unproven.
What this interaction means in plain words
Enzalutamide and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enzalutamide belongs to Endocrine; Liposomal doxorubicin belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4 and possibly P-gp, which may modestly increase doxorubicin clearance.
What to do
No routine dose change is needed; monitor for reduced antitumor response and continue standard cardiac and hematologic monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Enzalutamide and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzalutamide is a strong CYP3A4 inducer and could in theory lower exposure to doxorubicin. However, CYP3A4 is a minor route for doxorubicin clearance, so the clinical effect is probably small and unproven.
How serious is the interaction between Enzalutamide and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for reduced antitumor response and continue standard cardiac and hematologic monitoring.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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