Drug interactions
Enzalutamide + Lomitapide
Severity: Moderate
Enzalutamide and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower lomitapide exposure and reduce LDL-lowering efficacy. Lomitapide is a sensitive CYP3A4 substrate.
What this interaction means in plain words
Enzalutamide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
Enzalutamide induces CYP3A4, increasing lomitapide clearance.
What to do
Monitor LDL cholesterol after starting or stopping enzalutamide and adjust the lomitapide dose as needed. Consider alternatives if lipid control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Enzalutamide with Lomitapide?
MediHelp rates the interaction as moderate. Enzalutamide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower lomitapide exposure and reduce LDL-lowering efficacy. Lomitapide is a sensitive CYP3A4 substrate.
How serious is the interaction between Enzalutamide and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LDL cholesterol after starting or stopping enzalutamide and adjust the lomitapide dose as needed. Consider alternatives if lipid control is lost.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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