Drug interactions
Enzalutamide + Lovastatin
Severity: Moderate
Enzalutamide and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially reduce exposure to CYP3A4 substrates such as lovastatin. This may lead to loss of lipid-lowering efficacy.
What this interaction means in plain words
Enzalutamide and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Lovastatin belongs to Cardiovascular.
Why it happens
Enzalutamide induces CYP3A4, accelerating lovastatin clearance.
What to do
Monitor the lipid profile and consider switching to a statin not dependent on CYP3A4, such as rosuvastatin or pravastatin. If lovastatin is continued, adjust the dose to lipid response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Lovastatin?
MediHelp rates the interaction as moderate. Enzalutamide and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially reduce exposure to CYP3A4 substrates such as lovastatin. This may lead to loss of lipid-lowering efficacy.
How serious is the interaction between Enzalutamide and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and consider switching to a statin not dependent on CYP3A4, such as rosuvastatin or pravastatin. If lovastatin is continued, adjust the dose to lipid response.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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