Drug interactions
Enzalutamide + Macimorelin
Severity: Moderate
Enzalutamide and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers can reduce macimorelin exposure and lower the growth hormone response, possibly causing a false positive diagnosis of growth hormone deficiency. This affects test interpretation rather than ongoing therapy.
What this interaction means in plain words
Enzalutamide and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Macimorelin belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, decreasing macimorelin plasma levels and its stimulated GH release.
What to do
Where possible stop enzalutamide with adequate washout before macimorelin testing, or interpret results cautiously. Use an alternative stimulation test if enzalutamide cannot be paused.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Enzalutamide with Macimorelin?
MediHelp rates the interaction as moderate. Enzalutamide and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers can reduce macimorelin exposure and lower the growth hormone response, possibly causing a false positive diagnosis of growth hormone deficiency. This affects test interpretation rather than ongoing therapy.
How serious is the interaction between Enzalutamide and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible stop enzalutamide with adequate washout before macimorelin testing, or interpret results cautiously. Use an alternative stimulation test if enzalutamide cannot be paused.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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