Drug interactions
Enzalutamide + Nisoldipine
Severity: Major
Enzalutamide and Nisoldipine: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nisoldipine undergoes extensive CYP3A4 first-pass metabolism, and strong inducers markedly reduce its bioavailability. Blood pressure control may be lost.
What this interaction means in plain words
Enzalutamide and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Nisoldipine belongs to Cardiovascular.
Why it happens
Enzalutamide induces intestinal and hepatic CYP3A4, reducing nisoldipine bioavailability.
What to do
Avoid the combination; use an antihypertensive that is not a sensitive CYP3A4 substrate. If unavoidable, monitor blood pressure and titrate the dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Enzalutamide with Nisoldipine?
MediHelp rates the interaction as major. Enzalutamide and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nisoldipine undergoes extensive CYP3A4 first-pass metabolism, and strong inducers markedly reduce its bioavailability. Blood pressure control may be lost.
How serious is the interaction between Enzalutamide and Nisoldipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antihypertensive that is not a sensitive CYP3A4 substrate. If unavoidable, monitor blood pressure and titrate the dose.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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