Drug interactions
Enzalutamide + Omeprazole
Severity: Moderate
Enzalutamide and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide induces CYP3A4 and CYP2C19, which may reduce omeprazole exposure and weaken acid suppression.
What this interaction means in plain words
Enzalutamide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Enzalutamide induction of CYP2C19 and CYP3A4 increases omeprazole metabolism.
What to do
Monitor symptom control and raise the PPI dose if needed, or use a PPI less dependent on CYP2C19.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Omeprazole?
MediHelp rates the interaction as moderate. Enzalutamide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide induces CYP3A4 and CYP2C19, which may reduce omeprazole exposure and weaken acid suppression.
How serious is the interaction between Enzalutamide and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and raise the PPI dose if needed, or use a PPI less dependent on CYP2C19.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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