Drug interactions
Enzalutamide + Osilodrostat
Severity: Moderate
Enzalutamide and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower osilodrostat exposure through CYP3A4 induction, which can reduce control of cortisol production in Cushing's disease.
What this interaction means in plain words
Enzalutamide and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Osilodrostat belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing osilodrostat clearance.
What to do
Monitor cortisol levels and symptoms when starting or stopping enzalutamide. Adjust osilodrostat dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enzalutamide and Osilodrostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Enzalutamide with Osilodrostat?
MediHelp rates the interaction as moderate. Enzalutamide and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower osilodrostat exposure through CYP3A4 induction, which can reduce control of cortisol production in Cushing's disease.
How serious is the interaction between Enzalutamide and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and symptoms when starting or stopping enzalutamide. Adjust osilodrostat dose as needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
