Drug interactions
Enzalutamide + Osimertinib
Severity: Major
Enzalutamide and Osimertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A induction by enzalutamide lowers osimertinib concentrations and may impair tumor control in EGFR-mutated lung cancer.
What this interaction means in plain words
Enzalutamide and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Osimertinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing osimertinib metabolism.
What to do
Avoid concurrent use. If it cannot be avoided, labeling suggests increasing the osimertinib dose and monitoring response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Enzalutamide with Osimertinib?
MediHelp rates the interaction as major. Enzalutamide and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A induction by enzalutamide lowers osimertinib concentrations and may impair tumor control in EGFR-mutated lung cancer.
How serious is the interaction between Enzalutamide and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If it cannot be avoided, labeling suggests increasing the osimertinib dose and monitoring response closely.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
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