Drug interactions
Enzalutamide + Ospemifene
Severity: Moderate
Enzalutamide and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower ospemifene concentrations, potentially reducing its efficacy for dyspareunia and vaginal dryness. Ospemifene is primarily cleared by CYP3A4 and CYP2C9.
What this interaction means in plain words
Enzalutamide and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Ospemifene belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C9, increasing ospemifene clearance.
What to do
Monitor for reduced therapeutic effect and consider an alternative if symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Enzalutamide with Ospemifene?
MediHelp rates the interaction as moderate. Enzalutamide and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower ospemifene concentrations, potentially reducing its efficacy for dyspareunia and vaginal dryness. Ospemifene is primarily cleared by CYP3A4 and CYP2C9.
How serious is the interaction between Enzalutamide and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic effect and consider an alternative if symptoms are not controlled.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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