Drug interactions
Enzalutamide + Rimegepant
Severity: Moderate
Enzalutamide and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is a CYP3A4 substrate, and strong or moderate inducers reduce its exposure. Acute migraine efficacy may be lost.
What this interaction means in plain words
Enzalutamide and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Rimegepant belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, increasing rimegepant clearance.
What to do
Avoid concurrent use as labeling recommends. Consider another acute migraine treatment such as a triptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Enzalutamide with Rimegepant?
MediHelp rates the interaction as moderate. Enzalutamide and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rimegepant is a CYP3A4 substrate, and strong or moderate inducers reduce its exposure. Acute migraine efficacy may be lost.
How serious is the interaction between Enzalutamide and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as labeling recommends. Consider another acute migraine treatment such as a triptan.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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