Drug interactions
Enzalutamide + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Major
Enzalutamide and Sofosbuvir-velpatasvir-voxilaprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide, a strong CYP3A4 inducer that also induces P-gp, may markedly reduce velpatasvir, voxilaprevir and sofosbuvir exposure. This could cause HCV treatment failure.
What this interaction means in plain words
Enzalutamide and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Enzalutamide induces CYP3A4 and P-gp, accelerating clearance of the antiviral components.
What to do
Avoid the combination and defer HCV therapy until enzalutamide can be stopped, or seek specialist advice on alternatives. If unavoidable, monitor HCV RNA closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as major. Enzalutamide and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide, a strong CYP3A4 inducer that also induces P-gp, may markedly reduce velpatasvir, voxilaprevir and sofosbuvir exposure. This could cause HCV treatment failure.
How serious is the interaction between Enzalutamide and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and defer HCV therapy until enzalutamide can be stopped, or seek specialist advice on alternatives. If unavoidable, monitor HCV RNA closely.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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