Drug interactions
Enzalutamide + Solifenacin
Severity: Moderate
Enzalutamide and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially lower solifenacin concentrations, possibly causing loss of efficacy for overactive bladder.
What this interaction means in plain words
Enzalutamide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Solifenacin belongs to Genitourinary.
Why it happens
Strong CYP3A4 induction increases solifenacin clearance.
What to do
Monitor symptom control and consider a higher solifenacin dose within the labeled maximum, or an alternative agent not dependent on CYP3A4 if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Solifenacin?
MediHelp rates the interaction as moderate. Enzalutamide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially lower solifenacin concentrations, possibly causing loss of efficacy for overactive bladder.
How serious is the interaction between Enzalutamide and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider a higher solifenacin dose within the labeled maximum, or an alternative agent not dependent on CYP3A4 if response is inadequate.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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