Drug interactions
Enzalutamide + Tazemetostat
Severity: Moderate
Enzalutamide and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and could modestly lower enzalutamide exposure. Enzalutamide, a strong inducer, would also be expected to reduce tazemetostat levels, potentially lowering its efficacy.
What this interaction means in plain words
Enzalutamide and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Mutual CYP3A4 induction, with enzalutamide strongly increasing tazemetostat clearance.
What to do
Avoid concomitant strong inducers with tazemetostat where possible, otherwise monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Enzalutamide with Tazemetostat?
MediHelp rates the interaction as moderate. Enzalutamide and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and could modestly lower enzalutamide exposure. Enzalutamide, a strong inducer, would also be expected to reduce tazemetostat levels, potentially lowering its efficacy.
How serious is the interaction between Enzalutamide and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant strong inducers with tazemetostat where possible, otherwise monitor treatment response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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