Drug interactions
Enzalutamide + Tecovirimat
Severity: Minor
Enzalutamide and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and a weak CYP2C19 and CYP2C8 inhibitor, so enzalutamide exposure could change slightly in either direction. The overall effect is likely small.
What this interaction means in plain words
Enzalutamide and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enzalutamide belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction and weak CYP2C8/2C19 inhibition by tecovirimat alter enzalutamide metabolism.
What to do
No empiric dose change is needed; monitor for enzalutamide adverse effects and efficacy during the short tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Enzalutamide with Tecovirimat?
MediHelp rates the interaction as minor. Enzalutamide and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and a weak CYP2C19 and CYP2C8 inhibitor, so enzalutamide exposure could change slightly in either direction. The overall effect is likely small.
How serious is the interaction between Enzalutamide and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for enzalutamide adverse effects and efficacy during the short tecovirimat course.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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