Drug interactions
Enzalutamide + Vemurafenib
Severity: Major
Enzalutamide and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and vemurafenib is partly cleared by CYP3A4. Concurrent use may lower vemurafenib exposure and reduce its antitumor effect.
What this interaction means in plain words
Enzalutamide and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Vemurafenib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolism of vemurafenib.
What to do
Avoid the combination where an alternative is available. If it cannot be avoided, monitor for loss of tumor response and consider a vemurafenib dose increase according to the labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Enzalutamide with Vemurafenib?
MediHelp rates the interaction as major. Enzalutamide and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and vemurafenib is partly cleared by CYP3A4. Concurrent use may lower vemurafenib exposure and reduce its antitumor effect.
How serious is the interaction between Enzalutamide and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative is available. If it cannot be avoided, monitor for loss of tumor response and consider a vemurafenib dose increase according to the labeling.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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