Drug interactions
Epcoritamab + Everolimus
Severity: Moderate
Epcoritamab and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab triggers cytokine release that can temporarily suppress CYP450 enzyme activity. This may raise everolimus concentrations, particularly around the first doses and during cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Everolimus belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP3A4 activity reduces the metabolism of everolimus.
What to do
Monitor for everolimus toxicity such as mucositis, pneumonitis and cytopenias during the period of cytokine release after epcoritamab doses. Check everolimus trough levels and reduce the dose if concentrations or adverse effects are elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Everolimus?
MediHelp rates the interaction as moderate. Epcoritamab and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab triggers cytokine release that can temporarily suppress CYP450 enzyme activity. This may raise everolimus concentrations, particularly around the first doses and during cytokine release syndrome.
How serious is the interaction between Epcoritamab and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity such as mucositis, pneumonitis and cytopenias during the period of cytokine release after epcoritamab doses. Check everolimus trough levels and reduce the dose if concentrations or adverse effects are elevated.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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