Drug interactions
Ephedrine + Lisdexamfetamine
Severity: Moderate
Ephedrine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sympathomimetics, and combined use can cause additive increases in blood pressure and heart rate. It can also cause anxiety, insomnia and arrhythmias. Patients with cardiovascular disease are at particular risk.
What this interaction means in plain words
Ephedrine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic effects through catecholamine release and direct adrenergic stimulation.
What to do
Monitor blood pressure and heart rate, and avoid unnecessary ephedrine-containing products. Reduce doses if cardiovascular symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Ephedrine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sympathomimetics, and combined use can cause additive increases in blood pressure and heart rate. It can also cause anxiety, insomnia and arrhythmias. Patients with cardiovascular disease are at particular risk.
How serious is the interaction between Ephedrine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid unnecessary ephedrine-containing products. Reduce doses if cardiovascular symptoms develop.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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