Drug interactions
Ephedrine + Prochlorperazine
Severity: Minor
Ephedrine and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines with alpha-blocking activity can blunt the pressor response to ephedrine or cause hypotension when it is used to treat it. Ephedrine may also counteract the sedative effect of prochlorperazine.
What this interaction means in plain words
Ephedrine and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade by prochlorperazine opposes sympathomimetic vasoconstriction.
What to do
Monitor blood pressure and heart rate; titrate ephedrine to effect and consider another vasopressor if the response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Prochlorperazine?
MediHelp rates the interaction as minor. Ephedrine and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines with alpha-blocking activity can blunt the pressor response to ephedrine or cause hypotension when it is used to treat it. Ephedrine may also counteract the sedative effect of prochlorperazine.
How serious is the interaction between Ephedrine and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate; titrate ephedrine to effect and consider another vasopressor if the response is poor.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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