Drug interactions
Ephedrine + Propofol
Severity: Minor
Ephedrine and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol-induced hypotension is commonly treated with ephedrine, but the pressor response may be variable and sometimes augmented.
What this interaction means in plain words
Ephedrine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Pharmacodynamic: ephedrine's sympathomimetic action offsets propofol vasodilation; the augmentation mechanism is not well established.
What to do
Titrate ephedrine in small boluses while monitoring blood pressure and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ephedrine and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Ephedrine with Propofol?
MediHelp rates the interaction as minor. Ephedrine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol-induced hypotension is commonly treated with ephedrine, but the pressor response may be variable and sometimes augmented.
How serious is the interaction between Ephedrine and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ephedrine in small boluses while monitoring blood pressure and heart rate.
What other medicines interact with Ephedrine?
MediHelp also lists interactions of Ephedrine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Ephedrine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
