Drug interactions
Ergocalciferol + Magnesium hydroxide
Severity: Moderate
Ergocalciferol and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases magnesium absorption, and with magnesium-containing antacids or laxatives this may cause hypermagnesemia in renal impairment. Healthy kidneys usually clear the excess.
What this interaction means in plain words
Ergocalciferol and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergocalciferol belongs to Musculoskeletal; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Vitamin D enhances intestinal magnesium uptake while reduced renal clearance causes accumulation.
What to do
Avoid chronic magnesium hydroxide use in patients with chronic renal failure on vitamin D. Monitor serum magnesium if the combination is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Ergocalciferol with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Ergocalciferol and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases magnesium absorption, and with magnesium-containing antacids or laxatives this may cause hypermagnesemia in renal impairment. Healthy kidneys usually clear the excess.
How serious is the interaction between Ergocalciferol and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic magnesium hydroxide use in patients with chronic renal failure on vitamin D. Monitor serum magnesium if the combination is required.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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