Drug interactions
Ergotamine + Fenfluramine
Severity: Major
Ergotamine and Fenfluramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release and may add to ergotamine's vasoconstrictive and serotonergic effects. This could cause hypertension, vasospasm or serotonin toxicity.
What this interaction means in plain words
Ergotamine and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasoconstrictive effects.
What to do
Avoid combining; monitor blood pressure and for serotonin syndrome if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Ergotamine with Fenfluramine?
MediHelp rates the interaction as major. Ergotamine and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenfluramine increases serotonin release and may add to ergotamine's vasoconstrictive and serotonergic effects. This could cause hypertension, vasospasm or serotonin toxicity.
How serious is the interaction between Ergotamine and Fenfluramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; monitor blood pressure and for serotonin syndrome if exposure occurs.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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