Drug interactions
Ergotamine + Propylhexedrine
Severity: Moderate
Ergotamine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant with vasoconstrictor action. Systemic absorption with ergotamine may add to vasoconstriction and blood pressure elevation.
What this interaction means in plain words
Ergotamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Additive sympathomimetic vasoconstriction.
What to do
Avoid regular use during ergotamine therapy and use saline-based nasal care instead. Monitor blood pressure and peripheral circulation if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Ergotamine with Propylhexedrine?
MediHelp rates the interaction as moderate. Ergotamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an inhaled sympathomimetic decongestant with vasoconstrictor action. Systemic absorption with ergotamine may add to vasoconstriction and blood pressure elevation.
How serious is the interaction between Ergotamine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use during ergotamine therapy and use saline-based nasal care instead. Monitor blood pressure and peripheral circulation if used.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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