Drug interactions
Ergotamine + Risperidone
Severity: Minor
Ergotamine and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is metabolized by CYP3A4 and risperidone is a weak substrate and not a significant inhibitor, so no meaningful pharmacokinetic interaction is expected. Theoretical serotonergic and dopaminergic overlap exists, and ergotamine can cause vasoconstriction and nausea. Clinically significant effects are uncommon.
What this interaction means in plain words
Ergotamine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and dopaminergic effects; mechanism not firmly established.
What to do
No dose change is required. Monitor for serotonin toxicity or neuroleptic malignant syndrome symptoms and limit ergotamine use to the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Risperidone?
MediHelp rates the interaction as minor. Ergotamine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotamine is metabolized by CYP3A4 and risperidone is a weak substrate and not a significant inhibitor, so no meaningful pharmacokinetic interaction is expected. Theoretical serotonergic and dopaminergic overlap exists, and ergotamine can cause vasoconstriction and nausea. Clinically significant effects are uncommon.
How serious is the interaction between Ergotamine and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor for serotonin toxicity or neuroleptic malignant syndrome symptoms and limit ergotamine use to the lowest effective dose.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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