Drug interactions
Ergotamine + Trazodone
Severity: Moderate
Ergotamine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is a CYP3A4 substrate, not a notable inhibitor, so ergot toxicity from this mechanism is unlikely. A theoretical additive serotonergic effect exists, and ergotamine has vasoconstrictive properties.
What this interaction means in plain words
Ergotamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; ergotamine has 5-HT receptor agonist effects.
What to do
Monitor for serotonin toxicity symptoms and limit ergotamine to the lowest effective dose. Avoid adding CYP3A4 inhibitors, which raise ergotamine toxicity risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Trazodone?
MediHelp rates the interaction as moderate. Ergotamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is a CYP3A4 substrate, not a notable inhibitor, so ergot toxicity from this mechanism is unlikely. A theoretical additive serotonergic effect exists, and ergotamine has vasoconstrictive properties.
How serious is the interaction between Ergotamine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity symptoms and limit ergotamine to the lowest effective dose. Avoid adding CYP3A4 inhibitors, which raise ergotamine toxicity risk.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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