Drug interactions
Ergotamine + Trimipramine
Severity: Moderate
Ergotamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic activity and tricyclics increase serotonin availability, so serotonin toxicity is theoretically possible with the combination. Ergotamine also causes vasoconstriction, adding to the importance of watching for adverse effects.
What this interaction means in plain words
Ergotamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects through serotonin receptor agonism and reuptake inhibition.
What to do
Monitor for signs of serotonin syndrome and for ergotism such as cold extremities or paresthesias. Use the lowest effective ergotamine dose and prefer an alternative acute migraine therapy if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Trimipramine?
MediHelp rates the interaction as moderate. Ergotamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic activity and tricyclics increase serotonin availability, so serotonin toxicity is theoretically possible with the combination. Ergotamine also causes vasoconstriction, adding to the importance of watching for adverse effects.
How serious is the interaction between Ergotamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and for ergotism such as cold extremities or paresthesias. Use the lowest effective ergotamine dose and prefer an alternative acute migraine therapy if possible.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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