Drug interactions
Ertugliflozin + Tolbutamide
Severity: Moderate
Ertugliflozin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an SGLT2 inhibitor to a sulfonylurea raises the likelihood of hypoglycemia. Labeling for ertugliflozin advises considering a lower dose of insulin secretagogue.
What this interaction means in plain words
Ertugliflozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-stimulated insulin release and SGLT2 inhibitor-induced glucosuria.
What to do
Consider lowering the tolbutamide dose when starting ertugliflozin. Monitor blood glucose and teach hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Tolbutamide?
MediHelp rates the interaction as moderate. Ertugliflozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an SGLT2 inhibitor to a sulfonylurea raises the likelihood of hypoglycemia. Labeling for ertugliflozin advises considering a lower dose of insulin secretagogue.
How serious is the interaction between Ertugliflozin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the tolbutamide dose when starting ertugliflozin. Monitor blood glucose and teach hypoglycemia recognition.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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