Drug interactions
Ertugliflozin-sitagliptin + Levofloxacin
Severity: Moderate
Ertugliflozin-sitagliptin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients with diabetes, which may disturb control on antidiabetic therapy. The effect is most notable in older patients and those with renal impairment.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell insulin release, producing dysglycemia that adds to the effects of antidiabetic drugs.
What to do
Monitor blood glucose during levofloxacin therapy and counsel the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and switch if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Levofloxacin?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients with diabetes, which may disturb control on antidiabetic therapy. The effect is most notable in older patients and those with renal impairment.
How serious is the interaction between Ertugliflozin-sitagliptin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during levofloxacin therapy and counsel the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and switch if significant dysglycemia occurs.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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