Drug interactions
Ertugliflozin-sitagliptin + Quetiapine
Severity: Moderate
Ertugliflozin-sitagliptin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine may cause hyperglycemia, weight gain and dyslipidemia, which can undermine glycemic control in patients taking antidiabetic drugs.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c at baseline and periodically on quetiapine. Titrate antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Quetiapine?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine may cause hyperglycemia, weight gain and dyslipidemia, which can undermine glycemic control in patients taking antidiabetic drugs.
How serious is the interaction between Ertugliflozin-sitagliptin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically on quetiapine. Titrate antidiabetic therapy if control worsens.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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