Drug interactions
Erythromycin lactobionate + Estradiol
Severity: Moderate
Erythromycin lactobionate and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may increase estradiol exposure. This may cause estrogenic adverse effects, though the effect is usually modest during short antibiotic courses.
What this interaction means in plain words
Erythromycin lactobionate and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Erythromycin inhibits CYP3A4-mediated estradiol metabolism.
What to do
Usually no change is needed for a short course; monitor for breast tenderness, nausea or bleeding changes. Consider estradiol dose reduction if prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Estradiol?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and may increase estradiol exposure. This may cause estrogenic adverse effects, though the effect is usually modest during short antibiotic courses.
How serious is the interaction between Erythromycin lactobionate and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed for a short course; monitor for breast tenderness, nausea or bleeding changes. Consider estradiol dose reduction if prolonged use.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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