Drug interactions
Erythromycin lactobionate + Goserelin
Severity: Moderate
Erythromycin lactobionate and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin can prolong QT and cause torsades de pointes, and goserelin may add to the effect. IV dosing gives higher peak levels, so the risk is higher with electrolyte disturbance or heart disease.
What this interaction means in plain words
Erythromycin lactobionate and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider a non-macrolide alternative in patients with QT risk factors. Otherwise obtain an ECG, correct electrolytes and infuse slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin lactobionate and Goserelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Goserelin
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Goserelin?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin can prolong QT and cause torsades de pointes, and goserelin may add to the effect. IV dosing gives higher peak levels, so the risk is higher with electrolyte disturbance or heart disease.
How serious is the interaction between Erythromycin lactobionate and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-macrolide alternative in patients with QT risk factors. Otherwise obtain an ECG, correct electrolytes and infuse slowly.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
