Drug interactions
Erythromycin lactobionate + Indacaterol
Severity: Moderate
Erythromycin lactobionate and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin can raise systemic indacaterol exposure, and both drugs can prolong the QT interval. This may increase beta-agonist adverse effects and arrhythmia risk, especially in patients who are acutely ill.
What this interaction means in plain words
Erythromycin lactobionate and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Indacaterol belongs to Respiratory.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, which reduces indacaterol clearance, and both drugs have additive QT-prolonging effects.
What to do
Monitor heart rate, serum potassium and ECG during coadministration, particularly in patients with cardiac disease or electrolyte disturbance. No dose change is typically needed at the 75 mcg dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Indacaterol?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin can raise systemic indacaterol exposure, and both drugs can prolong the QT interval. This may increase beta-agonist adverse effects and arrhythmia risk, especially in patients who are acutely ill.
How serious is the interaction between Erythromycin lactobionate and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, serum potassium and ECG during coadministration, particularly in patients with cardiac disease or electrolyte disturbance. No dose change is typically needed at the 75 mcg dose.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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