Drug interactions
Erythromycin lactobionate + Loratadine
Severity: Minor
Erythromycin lactobionate and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and raises loratadine and its metabolite concentrations. Studies have not shown meaningful QT prolongation or clinical harm from this at usual doses.
What this interaction means in plain words
Erythromycin lactobionate and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin lactobionate belongs to Anti Bacterial; Loratadine belongs to Respiratory.
Why it happens
CYP3A4 (and P-gp) inhibition by erythromycin reduces loratadine metabolism.
What to do
No dose change is generally needed. Monitor for increased sedation or palpitations, particularly with other QT-prolonging risks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Loratadine?
MediHelp rates the interaction as minor. Erythromycin lactobionate and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and raises loratadine and its metabolite concentrations. Studies have not shown meaningful QT prolongation or clinical harm from this at usual doses.
How serious is the interaction between Erythromycin lactobionate and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for increased sedation or palpitations, particularly with other QT-prolonging risks.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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