Drug interactions
Erythromycin lactobionate + Methylprednisolone
Severity: Moderate
Erythromycin lactobionate and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and reduces methylprednisolone clearance, raising steroid exposure. This can increase corticosteroid adverse effects such as hyperglycemia, fluid retention, mood change and infection risk. The effect is more relevant with high-dose or prolonged therapy.
What this interaction means in plain words
Erythromycin lactobionate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Methylprednisolone belongs to Endocrine.
Why it happens
Erythromycin inhibits CYP3A4 (and P-glycoprotein), decreasing methylprednisolone metabolism.
What to do
Monitor for steroid excess and reduce the methylprednisolone dose if needed. Consider an alternative antibiotic such as azithromycin when appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Methylprednisolone?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and reduces methylprednisolone clearance, raising steroid exposure. This can increase corticosteroid adverse effects such as hyperglycemia, fluid retention, mood change and infection risk. The effect is more relevant with high-dose or prolonged therapy.
How serious is the interaction between Erythromycin lactobionate and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for steroid excess and reduce the methylprednisolone dose if needed. Consider an alternative antibiotic such as azithromycin when appropriate.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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