Drug interactions
Erythromycin lactobionate + Nevirapine
Severity: Moderate
Erythromycin lactobionate and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower erythromycin concentrations, while erythromycin may raise nevirapine levels, possibly reducing antibacterial effect and increasing nevirapine toxicity.
What this interaction means in plain words
Erythromycin lactobionate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 while erythromycin inhibits it.
What to do
Monitor antibacterial response and nevirapine adverse effects such as rash and liver enzyme elevation, or use azithromycin as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Nevirapine?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower erythromycin concentrations, while erythromycin may raise nevirapine levels, possibly reducing antibacterial effect and increasing nevirapine toxicity.
How serious is the interaction between Erythromycin lactobionate and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antibacterial response and nevirapine adverse effects such as rash and liver enzyme elevation, or use azithromycin as an alternative.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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