Drug interactions
Erythromycin lactobionate + Palbociclib
Severity: Moderate
Erythromycin lactobionate and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can increase palbociclib exposure. This may heighten the risk of neutropenia and other adverse effects of palbociclib.
What this interaction means in plain words
Erythromycin lactobionate and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Palbociclib belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of palbociclib, reducing its clearance.
What to do
Use a non-CYP3A4-inhibiting antibiotic where possible. If coadministration is needed, monitor complete blood counts frequently and reduce the palbociclib dose if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Palbociclib?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and can increase palbociclib exposure. This may heighten the risk of neutropenia and other adverse effects of palbociclib.
How serious is the interaction between Erythromycin lactobionate and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-CYP3A4-inhibiting antibiotic where possible. If coadministration is needed, monitor complete blood counts frequently and reduce the palbociclib dose if neutropenia develops.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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