Drug interactions
Erythromycin lactobionate + Pravastatin
Severity: Moderate
Erythromycin lactobionate and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin may raise pravastatin concentrations and increase the risk of myopathy. Pravastatin is not much dependent on CYP3A4, so the effect is smaller than with other statins, but it is still recognised.
What this interaction means in plain words
Erythromycin lactobionate and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Pravastatin belongs to Cardiovascular.
Why it happens
Erythromycin inhibits OATP1B1-mediated hepatic uptake of pravastatin and may increase its intestinal absorption.
What to do
Monitor for muscle pain, weakness or dark urine during the antibiotic course and check CK if symptoms develop. Consider temporarily holding pravastatin during short IV therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Pravastatin?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin may raise pravastatin concentrations and increase the risk of myopathy. Pravastatin is not much dependent on CYP3A4, so the effect is smaller than with other statins, but it is still recognised.
How serious is the interaction between Erythromycin lactobionate and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or dark urine during the antibiotic course and check CK if symptoms develop. Consider temporarily holding pravastatin during short IV therapy.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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