Drug interactions
Erythromycin lactobionate + Sevoflurane
Severity: Major
Erythromycin lactobionate and Sevoflurane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin produces higher peak concentrations and is associated with QT prolongation and torsades de pointes. Sevoflurane adds to QTc prolongation, increasing arrhythmia risk.
What this interaction means in plain words
Erythromycin lactobionate and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation through blockade of cardiac potassium channels.
What to do
Check QTc and electrolytes before anesthesia and consider a non-QT-prolonging antibiotic. If used, infuse slowly and monitor the ECG continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sevoflurane
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Sevoflurane?
MediHelp rates the interaction as major. Erythromycin lactobionate and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin produces higher peak concentrations and is associated with QT prolongation and torsades de pointes. Sevoflurane adds to QTc prolongation, increasing arrhythmia risk.
How serious is the interaction between Erythromycin lactobionate and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check QTc and electrolytes before anesthesia and consider a non-QT-prolonging antibiotic. If used, infuse slowly and monitor the ECG continuously.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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