Drug interactions
Erythromycin lactobionate + Sotalol
Severity: Major
Erythromycin lactobionate and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin lactobionate produces higher peak concentrations and is notably associated with QT prolongation and torsades de pointes. Added to sotalol, the risk of serious ventricular arrhythmia is increased, particularly with electrolyte disturbance.
What this interaction means in plain words
Erythromycin lactobionate and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Sotalol belongs to Cardiovascular.
Why it happens
Additive IKr potassium channel blockade leading to delayed ventricular repolarization.
What to do
Avoid if an alternative antibiotic is available. If needed, use continuous ECG monitoring, correct potassium and magnesium, and infuse slowly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Sotalol?
MediHelp rates the interaction as major. Erythromycin lactobionate and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin lactobionate produces higher peak concentrations and is notably associated with QT prolongation and torsades de pointes. Added to sotalol, the risk of serious ventricular arrhythmia is increased, particularly with electrolyte disturbance.
How serious is the interaction between Erythromycin lactobionate and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic is available. If needed, use continuous ECG monitoring, correct potassium and magnesium, and infuse slowly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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