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Drug interactions

Erythromycin lactobionate + Temsirolimus

Severity: Major

Erythromycin lactobionate and Temsirolimus: major interaction.

Last updated Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Intravenous erythromycin inhibits CYP3A4 and can increase concentrations of temsirolimus and its active metabolite sirolimus. This raises the risk of dose-related toxicity such as stomatitis, cytopenias, infection and metabolic disturbance.

What this interaction means in plain words

Erythromycin lactobionate and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Erythromycin lactobionate belongs to Anti Bacterial; Temsirolimus belongs to Oncology.

Evidence level: Moderate

Why it happens

Inhibition of CYP3A4-mediated metabolism of temsirolimus and sirolimus.

What to do

Choose a non-CYP3A4-inhibiting antibiotic such as azithromycin if feasible; otherwise monitor closely for toxicity and consider reducing the temsirolimus dose.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Frequently asked questions

Can I take Erythromycin lactobionate with Temsirolimus?

MediHelp rates the interaction as major. Erythromycin lactobionate and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin inhibits CYP3A4 and can increase concentrations of temsirolimus and its active metabolite sirolimus. This raises the risk of dose-related toxicity such as stomatitis, cytopenias, infection and metabolic disturbance.

How serious is the interaction between Erythromycin lactobionate and Temsirolimus?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-CYP3A4-inhibiting antibiotic such as azithromycin if feasible; otherwise monitor closely for toxicity and consider reducing the temsirolimus dose.

What other medicines interact with Temsirolimus?

MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.

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