Drug interactions
Erythromycin lactobionate + Tiotropium-olodaterol
Severity: Moderate
Erythromycin lactobionate and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin can prolong the QT interval and beta2 agonists such as olodaterol can add cardiac effects including hypokalemia and tachycardia. Together they may raise the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Erythromycin lactobionate and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation increasing arrhythmia susceptibility.
What to do
Check baseline ECG and correct potassium and magnesium before combining, and monitor for palpitations or syncope. Consider a non-macrolide antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin can prolong the QT interval and beta2 agonists such as olodaterol can add cardiac effects including hypokalemia and tachycardia. Together they may raise the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Erythromycin lactobionate and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before combining, and monitor for palpitations or syncope. Consider a non-macrolide antibiotic in patients with other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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