Drug interactions
Eslicarbazepine + Liothyronine
Severity: Minor
Eslicarbazepine and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak enzyme inducer and may modestly speed up the clearance of thyroid hormones. In patients on replacement therapy this could lower thyroid hormone exposure and, occasionally, unmask hypothyroidism.
What this interaction means in plain words
Eslicarbazepine and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Why it happens
Induction of hepatic glucuronidation and related metabolic pathways by eslicarbazepine may increase thyroid hormone clearance.
What to do
Check TSH and free thyroid hormone levels after starting or stopping eslicarbazepine in patients on liothyronine. Adjust the liothyronine dose only if there are signs of hypothyroidism or abnormal results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Eslicarbazepine with Liothyronine?
MediHelp rates the interaction as minor. Eslicarbazepine and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine is a weak enzyme inducer and may modestly speed up the clearance of thyroid hormones. In patients on replacement therapy this could lower thyroid hormone exposure and, occasionally, unmask hypothyroidism.
How serious is the interaction between Eslicarbazepine and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH and free thyroid hormone levels after starting or stopping eslicarbazepine in patients on liothyronine. Adjust the liothyronine dose only if there are signs of hypothyroidism or abnormal results.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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