Drug interactions
Eslicarbazepine + Metoclopramide
Severity: Moderate
Eslicarbazepine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause dizziness, somnolence and other CNS effects. Metoclopramide may also lower seizure threshold in susceptible patients, which is relevant for those on antiepileptics.
What this interaction means in plain words
Eslicarbazepine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS effects; metoclopramide has been reported to lower seizure threshold, opposing anticonvulsant action.
What to do
Monitor for sedation and changes in seizure control. Prefer an alternative antiemetic in patients with poorly controlled epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Metoclopramide?
MediHelp rates the interaction as moderate. Eslicarbazepine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause dizziness, somnolence and other CNS effects. Metoclopramide may also lower seizure threshold in susceptible patients, which is relevant for those on antiepileptics.
How serious is the interaction between Eslicarbazepine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and changes in seizure control. Prefer an alternative antiemetic in patients with poorly controlled epilepsy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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